Characteristics of short-chain alcohol dehydrogenases and related enzymes
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منابع مشابه
Alcohol dehydrogenases and aldehyde dehydrogenases.
T h e structure, function and evolution of alcohol dehydrogenases and aldehyde dehydrogenases have been studied for several years. Recent progress o n these aspects has been considerable and allows extensive conclusions to be drawn about the relationships and properties of these enzymes. Further aspects have also become available for study, such as the regulation of enzyme expression and the an...
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Halohydrin dehalogenases, also known as haloalcohol dehalogenases or halohydrin hydrogen-halide lyases, catalyze the nucleophilic displacement of a halogen by a vicinal hydroxyl function in halohydrins to yield epoxides. Three novel bacterial genes encoding halohydrin dehalogenases were cloned and expressed in Escherichia coli, and the enzymes were shown to display remarkable differences in sub...
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Retinoic acid biosynthesis in vertebrates occurs in two consecutive steps: the oxidation of retinol to retinaldehyde followed by the oxidation of retinaldehyde to retinoic acid. Enzymes of the MDR (medium-chain dehydrogenase/reductase), SDR (short-chain dehydrogenase/reductase) and AKR (aldo-keto reductase) superfamilies have been reported to catalyse the conversion between retinol and retinald...
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9. Doonan, S., Martini, F., Angelaccio, S., Pascarella, S., Barra, D. & Bossa, F. ( 1986) J. Moi. Evol. 23, 328-335 McAllister-Henn, L. ( 1988) Trends Biocherrr. .ki . 13, 1781 8 1 Doyle, J. M. (1988) Ph.D. Thesis, National University of Ireland Martini, F., Angelaccio, S., Barra, D., Pascarella, S., Maras, B., Doonan. S. & Bossa, F. (1985) Hiochirn. Hiophys. Actcr 832, 46-5 I Lipman. D. J . & ...
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Short-chain alcohol dehydrogenases (SCAD) constitute a large and diverse family of ancient origin. Several of its members play an important role in human physiology and disease, especially in the metabolism of steroid substrates (e.g., prostaglandins, estrogens, androgens, and corticosteroids). Their involvement in common human disorders such as endocrine-related cancer, osteoporosis, and Alzhe...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 1991
ISSN: 0014-2956,1432-1033
DOI: 10.1111/j.1432-1033.1991.tb16216.x